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Osteoclasts formation not only is regulated by RANKL (Receptor Activator for Nuclear Factor k B Ligand) and M-CSF (Macrophage Colony-stimulating factor), but also by osteoblasts. If the number and activity of osteoblasts exceed the the number and activity of osteoclasts, the buildup of new bones will exceed the breakdown of old bones. In Nuliv's in vitro study, a significant increase of osteoblasts were observed. In vivo (animal) study on OsteoSine complex™ NuLiv has completed two in vivo (animal) studies on OsteoSine Complex™. They are the PO (post-overiectomized) and the RA (Retinoic acid-induced acute osteoporosis) models. The PO model equates to menopause and post menopause women, and the RA model represents a none gender and age independent model. In the RA (accelerated bone loss) model, the effect of OsteoSine Complex™ on s-SGP, b-ALP, S-TRAP, and s-Ca; bone ash weight, bone ash calcium and phosphate weight; and spine and femoral head weight (g/cm2), average trabecular bone surface and width were studied and measured. In the PO (decreased hormone) model, the effect of OsteoSine Complex™ on changes in weight in lumber spine and femoral head; bone ash, bone ash calcium and phosphate weight were studied and measured. The effect of OsteoSine Complex™ on all the important parameters mentioned above compared against nilestriol were also studied. Due to FDA regulation, NuLiv is not allowed to present the results of its PO, RA, and Nilestriol studies here. But the results of these studies give NuLiv absolute confidence that OsteoSine™ can work for the vast majority of people who take it. We are willing to offer a 1 year money back guarantee for any one who is committed to taking OsteoSine™ on a regular basis. For details, see the "1 year money back guarantee program". Human results on OsteoSine™ In the last 3 years since NuLiv started offering OsteoSine™ to the public, it has received before-after DEXA scan reports from its customers from different parts of USA. Again, due to FDA regulations, NuLiv is not allowed to present the numbers here. See the "1 year money back guarantee program" for a risk free trial of OsteoSine™. Safety of OsteoSine™ The plants from which OsteoSine Complex™ is extracted from have been safely used for centuries in East Asia. NuLiv has also completed Acute, sub-acute, LD50, and mutagenicity studies on OsteoSine Complex™. They are the standard tests required for pharmaceutical drugs and are costly and require special knowledge and equipment to carry out. Other ingredients in OsteoSine™ are essential vitamins and minerals that can be found in all types of food and are the necessary nutrients for good health. OsteoSine™ is very safe to use at its recommended dosage. Benefit of other ingredients Vitamin D3: for calcium absorption. Vitamin K2: bone proteins are dependent on vitamin K for their synthesis. Calcium: a basic building material for bone matrix. Magnesium: critical to calcium utilization. Zinc: important for calcium uptake. Copper: aids in the formation of bone. Manganese: vital in mineral metabolism, and may help prevent osteoporosis. Boron: improve calcium absorption.
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