The various herbs and botanicals found in SleepWell™ have been proven in traditional medicine and peer reviewed journals to assist with healthy sleep. In fact, the research behind 5-htp is strong enough that some developed countries prescribe it for various sleep disorders.
Lemon Balm, Passion Flower, Hops & Valerian. The powerful herbs behind SleepWell™
Zizyphus, Polygala and Angelica extracts in SleepWell™ have been used over centuries in TCM (Traditonal Chinese Medicine) to soothe and relax human mind and body.
The plant extracts of Valerian, Hops, Lemon Balm and Passion flower in SleepWell™ have been used in Western cultures, some of them dated back to the ancient Greek time, to provide synergistic effects to Zizyphus, Polygala and Angelica in calming the mind and body.
The proprietary Wulinshen Prime™ in SleepWell™ then provides the critical, necessary and often depleted nutrients to the brain and assist in the biochemical process in the brain to promote restful and deeper sleep so one will wake up fully refreshed and energized.
L-theanine is a free form amino acid found in green tea and is available as a supplement. Clinical studies have shown that 100-200 mg of L-theanine taking orally induces calmness in people. L-theanine also appears to assist in the formation of the inhibitory neurotransmitter Gamma Amino Butyric Acid (GABA). GABA blocks the release of the neurotransmitters dopamine and serotonin and leads the brain to a relaxation state.
L-theanine is safe to take at the 200 mg level contained in SleepWell™ as it is a natural substance found in tea, the most consumed beverage worldwide after water for thousands of years around the world. It is estimated that 6-8 cups of tea contain between 200 to 400 mg of L-theanine.
Melatonin is an important hormone secreted by the pineal gland, a small gland in the center of the brain. Melatonin is one of the best aids for sleep. In several studies, supplementation with Melatonin has been found helpful in inducing and maintaining sleep in both children and adults, for both people with normal sleep patterns and those suffering from insomnia. However, it appears that the sleep-promoting effects of Melatonin are most apparent only if a person's Melatonin level is low. In other words, it will only produce a sedative effect when the Melatonin level is low.
5-Hydroxytryptophan (5-HTP), a metabolite of tryptophan, is converted in the brain to serotonin - an important initiator of sleep. It is well known that elevated levels of serotonin may have a calming, soothing effect on the mind and body. 5-HTP has also been reported, in numerous double-blind clinical studies, to decrease the time required to get to sleep and to decrease the number of awakenings. There are some caveats to 5-htp, including not taking 5-htp with anti-depressants and barbiturates. Studies indicate 5-htp can be taken in sufficiently large dosages without any harmful side effects.
Angelica sinensis or "female ginseng" is a herb from the family Apiaceae, indigenous to China. Its root is commonly known in Chinese as dong quai or danggui and is widely used in Chinese traditional medicine for gynecological ailments, fatigue, mild anemia and high blood pressure. The plant's phytochemicals consist of coumarins, phytosterols, polysaccharides, ferulate, and flavonoids.
The root has, among many other properties, a sedative and vasodilating properties. The volatile elements in Angelica can relax the muscle.
Hops (Humulus lupus) is a Eurasian climbing shrub seen growing along road sides. The parts used are the female flowers (strobiles). Its active chemical compounds are alpha bitter acid and flavonoids. Historically Hops have been used as a sleeping aid. Pillows filled with Hops were used to sleep on. Hops was first used in England in the 16th century to flavor beer. Hops are still used in Europe as a natural alternative for sleeplessness. No toxicity has been reported.
Hops cause sedation and sleepiness in animals. Most studies in humans have tested the effects of Hops on sleep quality when used in combination with Valerian (Valeriana officinalis).
Lemon balm extract
Lemon balm (Melissa officinalis), a member of the mint family, is considered a "calming" herb. It was used in the Middle Ages to reduce stress and anxiety and promote sleep. Today, Lemon balm is often combined with other calming, soothing herbs, such as Valerian, chamomile, and Hops, to enhance the overall relaxing effect.
Several studies have found that Lemon balm combined with other calming herbs (such as Valerian, Hops) helps reduce anxiety and promote sleep. For example, in one recent study of people with minor sleep disorders, those who ingested an herbal combination of Valerian and Lemon balm reported sleeping much better than those who ingested placebo pills.
In a recent double-blind, placebo-controlled study, 18 healthy volunteers received either 300 mg or 600 mg standardized Lemon balm extract or placebo for 7 days. The 600 mg dose of Lemon balm increased mood and significantly increased calmness and alertness.
Passion flower extract
Passion flower (Passiflora incarnata) was used in traditional remedies as a "calming" herb for anxiety and insomnia. During the early twentieth century, this herb was included in many over-the-counter sedatives and sleep aids. In Germany, Passion flower is available as an over-the-counter sedative (in combination with other calming herbs such as Valerian and Lemon balm). It is also used in German homeopathic medicine for pain, insomnia, and nervous restlessness. Today, professional herbalists use Passion flower (often in combination with other calming herbs) for insomnia, tension, and other health problems related to anxiety and nervousness.
Polygala tenuifolia extract
Polygala tenuifolia (Polygala tenuifllia Willd), or "yuanzhi", is a tall perennial plant that has been cultivated throughout East Asia for centuries. The root of Polygala tenuifolia has been used in traditional Chinese medicine to mediate sedative effect on the central nervous system. It has also been used for insomnia, among other things.
The main compounds in Polygala tenuifolia are the saponins which have been suggested to have tranquillizing effects on human body. Laboratory animal studies showed that the group of mice receiving Polygala tenuifolia extract exhibited considerable calmness comparing to the control group.
According to a Japanese Medical Society conference report, Polygala tenuifolia and the active chemical compounds in Zizyphus jujuba spinosa, 3,4,5-trimethoxyl cinnamic acid (TMCA) and spinosin, improved the sleeping time of Wistar rats in a Pentobarbitol-induced hypothermal model and in a corticotropin releasing hormone (CRH) model.
Valerian root extract
Valerian (Valeriana officinalis), also known as Capon's Tail, English Valerian, is a tall perennial herb, native to Europe. The root and rhizome is used medicinally. Its active chemical compounds are Valeric acid or valerenic acid. Valerian was known to Dioscorides (A.D. 41-68) in ancient Rome and has been used since that time as a mild sedative. Valerian is used extensively in Europe as a mild sleep aid and for anxiety. Several clinical studies on humans have shown that it safely relieve occasional insomnia. Valerian is generally recognized as safe and approved for food use by the U.S.F.D.A. (from National Institutes of Health, Office of Dietary Supplements, www.ods.od.nih.gov/factsheets/valerian.asp)
Wulinshen Prime™ is a proprietary Xylaria Nigripes extract produced by a patented fermentation technology available from NuLiv Science only. Wulinshen Prime™ contains many essential amino acids, vitamins, minerals, trace elements, glycoproteins, glutamic acid, γ-aminobutyric acid (GABA) and glutamate decarboxylase. It is well established that glutamic acid assists the uptake of GABA to specific brain cell receptors. GABA's main function is to inhibit excitatory neuro-activities to exert a tranquilizing effect on the central nerve system. Glutamate decarboxylase (GAD) is involved in the synthesis of GABA.
Pharmacological studies (Ref. 1) indicate that the contents of glutamic acid (Glu), γ-aminobutyric acid (GABA) and the binding affinity of GABA receptors in the brain were found to be augmented in the subjects after the administration of Wulinshen Prime™. Furthermore, the activity of glutamate decarboxylase (GAD) was also elevated. All these suggest that Wulinshen Prime™ possesses the ability to facilitate the entry of Glu and GABA into the brain to activate the GABA receptors and thus exerts its sedative and sleep-promoting and mood-elevating properties.
Zizyphus jujuba Mill var. spinosa Hu extract
Zizyphus jujuba is a small deciduous tree in the buckthorn family. It is thought to be native to North Africa and Syria but moved eastward through India to China where it has been cultivated for over 4,000 years. A unique triterpenes found in Zizyphus is jujubosides. Other active compounds found in Zizyphus seed are flavone and zizyphus seed oil. All these compounds have been suggested to have sedative effect on human body and mind.
Laboratory animal studies of Zizyphus extract confirm its sedative effect. Zizyphus is reported to have no toxicity when taken orally. In laboratory animals (mice and rats), a huge single dose of 50 grams of Zizyphus extract per kilogram of body weight and a daily dose of 20 grams per kilogram for 30 days did not produce toxic symptoms. Pharmacological evaluations suggested that prolonged feeding of Zizyphus seed oil or Zizyphus extract to animals can have beneficial effects on their serum triglycerides and cholesterol (mainly LDL) levels as well as the fatty content of their livers. These properties have also been attributed to the triterpenes found in ginseng and ganoderma.
Safety of SleepWell™
All ingredients in SleepWell™ have been used in Eastern and Western cultures for centuries and have also been reported from numerous pharmacological studies to be extremely safe, especially at the comparatively low dosages found in SleepWell™. More importantly, the research behind many ingredients, including 5-htp, L-theanine and so on have shown that they are safe at low to moderate doses.
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